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Statin prescribing    

Changes/additions to materials:

MeReC Stop Press on NICE Clinical Guideline 67. 

NICE issued guidance on CV risk assessment and lipid modification in June 2008. The important changes are discussed in the MeReC Stop Press, which should be read in conjunction with the materials in this room of NPCi.

MHRA advice re fibrates - Drug Safety Update Vol 1, Issue 4. 4th. November 2007

The MHRA has issued revised advice to prescribers concerning the place in therapy of fibrates:
"Fibrates should be used as first-line therapy only in patients with isolated severe hypertriglyceridaemia. In patients who also have raised cholesterol, fibrates may be considered only when a statin or other effective treatments are contraindicated or not tolerated".

This is discussed in a MeReC Stop Press, which should be read in conjunction with the materials in this room of NPCi. 

Note that some of the materials apply the black triangle () to rosuvastatin. This was correct at their time of publication but the black triangle was removed by the MHRA in June 2007

Increasing low cost statin prescribing

Increasing low cost statin prescribing (prescription items for simvastatin and pravastatin as a percentage of the total number of prescriptions for all statins) is one of the "better value, better care" indicators of efficiency published by the NHS Institute in October 2006. These indicators identify areas for potential improvements in efficiency and will form part of a portfolio of NHS performance measures.

http://www.institute.nhs.uk/PriorityProgrammes/DeliveringQualityAndValue/better_value_better_care_indicators.htm

The volume of statin prescribing has increased several-fold during recent years and there are large differences in cost between the different drugs. By ensuring that clinicians initiate patients on one of the lower cost drugs, PCTs can keep statin prescribing costs down. In addition, many will wish to review prescribing of these drugs for patients prescribed one of the more costly versions.

The National Prescribing Centre has collated and published a range of resources to support organisations and individuals that are undertaking their own local statin switching initiatives.

Here is a list of the materials that are currently available through our websites www.npc.co.uk and www.npc.nhs.uk. Check back regularly as we will be adding new materials on an ongoing basis.

Please note that some of the resources are intended to be templates from which you can produce local versions, adapted to your own local needs. The remainder are not intended to be changed. The materials have been split into the four following directories:

Policy and guidance

GMS contract QOF targets for cholesterol 2006-07
Summary of GMS quality and outcome framework targets including points available in clinical areas.
                                                  
Summary of NICE guidance
An extract of NICE technology appraisal 94 —Statins for the prevention of cardiovascular events
                         
National policy on statin prescribing
Copy of the statement issued by Professor Roger Boyle, National Director for Heart Disease and Stroke, DH to clarify NHS policy for statin prescribing subsequent to the publication of JBS2 and NICE guidelines.

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Therapeutics

Lipid evidence PowerPoint presentation
Download a PowerPoint presentation to use in your discussions with prescribers around statin use. Extensive teaching notes are also available below.
                         
Lipid evidence PowerPoint presentation notes
Teaching notes to support the lipid evidence PowerPoint presentation.

Lipids data-focused commentary
Statin prescribing in the UK is increasing every month. Download this commentary to read about just how much is being prescribed and which ones are the ones being prescribed most often in your area. It also examines the evidence around the prescribing of rosuvastatin and ezetimibe and relates this to the prescribing data around the use of these agents.     

Lipids quiz
Test your knowledge of the evidence-base around statins with this quiz. Simply download the quiz, complete it, and then download the quiz and answers below to see how many you answered correctly.
                         
Lipids quiz and answers
Quiz and answers.

Lipids case study
Paul and Fiona have both seen an advert on TV about their cholesterol levels and come and ask your advice as to whether they should take a statin. Test how much you know about statin prescribing using these 'real world' examples. Download the case study first and then answer the questions contained within it. Then download the suggested answers and check to see if your choices are in line with the evidence-base.
                         
Lipids case study and answers  
Case study and answers.

Summary of potentially hazardous drug interactions –statins

A summary of the most important and common interactions with statins, published by the CHM/MHRA in Drug Safety Update 1(6) January 2008
             
Statins –a guide for patients
A guide to help prescribers discuss the risks and benefits of taking a statin with patients during a consultation. Presented in a simple pictorial format.

ELearning in less than 60 minutes
Five multimedia workshops each of 10 minutes duration looking at the evidence-base for the management of cardiovascular risk and lipids. Each workshop consists of a PowerPoint presentation accompanied by an pre-recorded audio commentary by one of the NPC team.

Instructions: You will need to download Interwise application software version 6 to play the workshops. Install this software by clicking here. If you are experiencing problems downloading this application software click here or alternatively contact your local IT helpdesk. The NPC cannot provide technical support to enable you to access these files. Once you have downloaded the application click here for further instructions on how to use the software.

Then choose the workshop you wish to view from the list below. The files have been zipped but once unzipped double click on the file name to start the presentation. You can stop the workshop at any time by clicking the pause button and then clicking play again to restart it. Requires use of Interwise application software.

Workshop 1 —Introduction and background
Workshop 2 —The evidence for different statins and different doses
Workshop 3 —High dose statin vs. ‘standard’doses
Workshop 4 —Choice of statin in individuals
Workshop 5 —Implementing the NICE guidance in practice

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Implementation resources

5 Minute Guide —High impact statin switching
A brief summary of approaches that have worked in other organisations that have made statin switches. Intended to provide some basic ideas for changes that lead to improvements. Designed for double-sided printing on A4 paper and to be folded into a small booklet.

5 Minute Guide —Principles of change management
A short introduction to key principles for managing change such as statin switching policies. Designed for double-sided printing on A4 paper and to be folded into a small booklet.

Template for a practice-based audit —Low-cost statin prescribing
A template for practices to enable them audit their statin prescribing before, during or after a switching campaign. Can be used as a tool to monitor progress. Intended for adaptation according to local circumstances or preferences.

Template for Standing Operating Procedure —Switching patients from high cost to low cost statin
A template SOP for use by practices or PCTs switching from high cost to low cost statins. Contains basic framework that is suitable for local adaptation.

Statin switch letter
Sample of a letter that could be used to inform patients of a change to their medicines. Template for local adaptation.

Template information leaflet for patients
Template for an information leaflet containing basic information to support a local statin switching campaign.

Practice switch recording form
Template form to record patients switched from high cost to low cost statin. Includes columns for documenting follow up blood results and LFTs etc. Fully customisable to suit local policies.

Template for discussion points on statin switching
A template containing some possible discussion points for consideration as part of a local statin switching campaign. Intended for use in discussions with prescribers.

Statin prescribing points
A summary of points for consideration when prescribing a statin. Intended for use in discussions with prescribers.

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Monitoring tools

Statin switch tracker and impact assessment tool
A simple-to-use tool for monitoring progress of a local statin switching campaigns. Enables practices or PCTs to set switching targets for individual drugs and dose forms. Produces charts of progress and can be used to give feedback to individual prescribers or practices. Detailed instructions for use are contained in the associated file Statin review tool.

Statin review tool
A user guide to accompany file Statin switch track.

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Acknowledgements

The National Prescribing Centre would like to acknowledge the support of all of the individuals and organisations that have shared their ideas, documents and other materials to enable us to create the resources for statin switching initiatives.

In particular, we would like to acknowledge the significant contribution made by the following organisations (click here), who have shared materials and ideas from their own statin switching campaigns with us.

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