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| Introduction
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`The New NHS - Modern and Dependable' White
Paper, published in December 1997, introduced major reforms to the NHS. One aspect is the
establishment of Primary Care Groups (PCGs), based upon populations of, on average, around
100,000, bringing together GPs and community nurses to work to improve the health of local
people. One consequence of this is to include all prescribing costs within a new, unified
and cash limited allocation.
To help PCGs manage their prescribing, the National
Prescribing Centre (NPC) has produced this booklet to help prescribing leads and PCG board
members to understand the language, phrases and terms associated with prescribing advice.
It also acts as an introduction to some of the systems, concepts and support available.
It is designed to provide a simple, user-friendly glossary of
commonly used terms, within the framework of managing the use of medicines.
Dr Robert Queenborough MRCGP MHSM
May 1999
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| Prescribing
analysis terms |
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| Patient
denominators (PUs, ASTRO-PUs, STAR-PUs) |
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Denominators provide a method of
comparing behaviour between different groups of prescribers. The various denominators have
developed over time as knowledge of what affects prescribing patterns is gained or the
ability to manipulate the information is available. Modern computing technology now allows
relatively rapid manipulation of the huge amounts of data required for the more complex
denominators. Information is available now at the click of a button which, until
relatively recently, took many hours, or even days, to produce.
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Prescribing Units (PUs) |
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PUs were developed to take account
of the greater need of elderly patients for medication when reporting prescribing
performance at both practice and Health Authority (HA) level. Patients aged 65 and over
are counted as three prescribing units and patients under 65 and temporary residents as
one.
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Age Sex Temporary Resident
Originated Prescribing Units (ASTRO-PUs) |
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Introduced in 1993 as a more
sophisticated weighting system than PUs, with a greater number of age bands. In the light
of further research the weightings of the age bands were adjusted in 1997. These are known
as ASTRO(97)-PUs.
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ASTRO-PU Weightings And patients
in Nursing Homes (ASTRaNHomes) |
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The ASTRO-PU weightings for
patients in Residential Homes are twice the value of the corresponding patients in their
own home, and for Nursing Homes, three times the value.
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Specific Therapeutic Group Age-Sex
Related Prescribing Units (STAR-PUs) |
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ASTRO-PUs are devised from the
total of all drug costs. STAR-PUs have been developed along similar lines but based on
costs within therapeutic groups. STAR(97)-PUs have been developed for the eight leading
therapeutic groups, i.e. gastrointestinal, cardiovascular, respiratory, central nervous
system, infection, endocrine, musculoskeletal and skin, which together account for 85% of
prescribing in England. The weightings are based on cost rather than on the number of
prescription items. |
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| Measures
of prescribing (DDD, ADQ, PDD) |
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Defined Daily Dose (DDD) |
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A system developed and maintained
by the World Health Organisation (WHO). Each drug is given a value that represents the
assumed average maintenance dose per day for a drug used for its main indication in
adults. The DDD is a unit of measurement, not a recommended dose, and may not be a real
dose.
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Average Daily Quantity (ADQ) |
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Whereas the DDD is defined by
international prescribing habits, the ADQ is based upon the prescribing behaviour within
England. It represents the assumed average maintenance dose per day for a drug used for
its main indication in adults. The ADQ is an analytical unit used to compare treatment
activity, and not a recommended dose.
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Average Monthly Quantities (AMQ) |
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A unit of measurement which is the
assumed average maintenance dose per month for a drug used for its main indication in
adults.
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Prescribed Daily Dose (PDD) |
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Average daily amount actually
prescribed by a specified group of prescribers. Difficult to determine using Prescription
Pricing Authority (PPA) data alone as the duration of each item is not available.
Therefore, need to use sample databases, such as the General Practice Research Database,
which contain this information. The PDD is an analytical unit, and may not be a real dose.
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Prescription item |
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A single entry on a prescription
form. This can be for a single tablet or many tablets. Items are not a good indicator of
total use unless total amounts are also being considered. Counting of items can be of
great value in measuring the frequency of prescribing and this is relevant to treatments
given largely, or entirely, in courses, e.g. antibiotics and immunisations. |
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| Deprivation/morbidity
indicators |
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Jarman |
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The Jarman underprivileged area
(UPA) score is used in the NHS for planning and to weight capitation payments to General
Practitioners (GPs). It is readily available by electoral ward from the public health
common dataset. The score is the weighted total of eight transformed and standardised
census variables and can be used to rank areas in order of deprivation; a score of 0 is
the mean for England. |
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The eight variables are the ward
percentages of elderly people living alone; households with children under five years; one
parent families; unskilled manual workers; unemployed people; overcrowded households;
residents who have changed address in the previous year; and head of household born in the
new commonwealth. An area with a larger score is more deprived than one with a lower
(including a negative) score.
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Low
Income Scheme Index (LISI) |
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A measure of deprivation based
upon claims for exemption from the prescription charge on the grounds of low income.
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Permanent sickness |
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Measure of deprivation that is the
largest single predictor, after age and sex profile, of difference between drug
expenditure between HAs. It accounts for about 57% of the observed difference. Based upon
those reporting themselves as `off work' because of permanent sickness. It is a direct
measure of morbidity.
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Townsend |
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This index of deprivation is based
on car ownership, unemployment, overcrowded housing, and housing tenure and reflects
levels of material deprivation. |
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| Prescription
Analysis and CosT (PACT) |
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Information on GP and Nurse
prescribing collected by the PPA following the reimbursement of community pharmacists and
dispensing doctors for dispensing FP10 prescriptions.
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The information is provided at
varying levels of complexity from a quarterly PACT standard report to detailed information
for periods of one or more months as catalogues. These catalogues can itemise drug
expenditure down to individual product presentation. |
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| Electronic
PACT (ePACT) |
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ePACT is an electronic version of
PACT which is held as a database on the PPA's mainframe computer. This database can be
queried and the results sent electronically to HAs for analysis. ePACT can be used to
produce information and graphs useful in the analysis of the prescribing patterns of
individual or groups of prescribers. A variety of electronic PACT versions are available
or are being developed for analysis of community nurse, PCG, HA, regional and national
prescription data.
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`ePACT.net' is a version of ePACT
available over the NHS net to authorised users. It is available at the ePACT.net website (http://www.epact.ppa.nhs.uk valid ID and password
required). |
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| Prescribing
monitoring documents system (PMD) formerly known as the Indicative Prescribing
Scheme (IPS) |
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The PMD system provides GPs,
nurses, PCGs, Trusts, HAs, Regional Offices and the NHS Executive with monthly expenditure
and forecasting reports on the cost of prescribing against their budgets. Once a year the
system is used in conjunction with NHS Executive guidelines and local knowledge to set
appropriate prescribing budgets for GP practices. GPs automatically receive a monthly
statement and an annual end of year return. |
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| Prescribing
Toolkit |
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The Prescribing Toolkit is a set
of measuring tools for the purpose of analysing PPA prescribing data. The data is
presented in the form of a set of national user-defined standard reports.
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The `Toolkit' concept was
introduced to address prescribing issues relevant to policy initiatives such as
performance management, budget setting, and incentive schemes.
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The Electronic Toolkit system was
developed to provide HAs, Regional Offices and the Department of Health (DoH) with data on
a range of standard initiatives and indicators.
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As a result of workshops held for medical and pharmaceutical
advisers the following Prescribing Toolkit reports were developed by the PPA:
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Specialist
Drugs Reports. From 1999, these reports will be produced annually in
November and will be based on annual data for the most recently available 12-month period.
This report shows a pre-defined list of high cost, more specialised drugs at national, HA
and practice level in a format similar to the PACT concise catalogue.
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Potential
Generic Savings Reports. From 1999, these reports will be produced twice a
year in June and early December, based on annual data. The June issue will be based on the
previous financial year, and the December issue on the most recently available 12-month
period. |
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Top 40 drugs by size of potential
saving at national level. |
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Top 30 drugs by size of potential
saving at HA level. |
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Top 20 drugs by size of potential
saving at practice level.
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Prescribing
Indicator Reports (formerly known as MEMPHIS) |
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Currently seven performance
indicators are contained within the Toolkit: |
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Expenditure on drugs of limited
clinical value (as defined by the Audit Commission). |
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Expenditure on premium priced
products - modified release (all systems of sustained release). |
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Expenditure on premium priced
preparations - combination products. |
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Benzodiazepines - DDDs per CNS
STAR-PU. |
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Cost per DDD - inhaled
corticosteroids. |
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DDDs for inhaled corticosteroids
per respiratory STAR-PU. |
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Percentage generic items.
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Additional indicators introduced
in 1998 are: |
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DDDs per STAR-PU for oral NSAIDs. |
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NIC per DDD for oral NSAIDs. |
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DDDs per STAR-PU for ulcer healing
drugs. |
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NIC per DDD for ulcer healing
drugs. |
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Items per STAR-PU for
antibacterials. |
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NIC per Item for antibacterials. |
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Number of months of treatment of
HRT per woman aged 45-64. |
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Average cost per month for HRT
treatment (NIC/ASTROPU).
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Health Authority level reports go
to HAs, Regional Offices and the NHS Executive. HAs also receive practice level reports,
which are available from the PPA website via NHSnet (valid ID and password required).
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Toolkit will be available to PCGs
from the PPA website via NHSnet from June 1999. This will give information down to
practice level, available for the preceeding two financial year's data (valid ID and
password required).
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u
Toolkit website: |
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| Financial
Terms |
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| Unified
budget |
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A single, cash-limited, budget
introduced for PCGs with effect from 1st April 1999. It consists of the commissioning,
prescribing and General Medical Services (GMS) infrastructure budgets (previously known as
the Hospital and Community Health Services (HCHS), prescribing and Cash-limited GMS
budgets). This brings prescribing costs within an overall cash limit. Implications are
that any overspend on the prescribing budget will need to counterbalanced by reductions in
expenditure in other parts of the budget. Conversely, underspending on the prescribing
budget will mean more money is available for other areas.
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Includes GMS staffing budget and
cost-rent schemes, but not GP remuneration.
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| Budgetary
expressions |
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Top-slice |
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Removal of an amount of money from
a budget before it is allocated generally to individual budget headings. Acts as a pool
for related purposes, e.g. incentives and contingencies.
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Non-recurrent monies |
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Budgets that are allocated for a
single financial year. Not usually used to fund posts, as continued funding can not be
guaranteed from one year to the next.
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Recurrent monies |
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Funds that are received into
budgets year on year. Staff salaries are usually remunerated from recurrent funds.
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Slippage |
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Slippage is the amount of money
remaining within a budgetary heading because the intended spend occurred later in the
financial year than planned. Therefore only part, if any, of the expected costs for that
year are incurred. Slippage is often used as a source of non-recurrent funds.
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Weighted capitation |
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Used for resource allocation. It
represents the number of patients in a population adjusted to take account of various
factors, e.g. age, sex, residency status and morbidity.
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`Cash-limited' |
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Budget of limited amount locally;
size of budget determined centrally.
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`Non-cash-limited' |
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Budget not limited locally within
a HA but limited within a central DoH budget. The NHS has a financial target within which
it has to operate. Overspending was dealt with centrally by the DoH until the introduction
of unified budgets, which means that the financial risk is now handled at a more local
level.
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Risk-management (financial) |
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Strategies by which budgets are
used to maximal effect and the impact of any overspend by unforeseen cost pressures is
minimised or removed completely (see also clinical risk management).
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| Drug cost
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Net Ingredient Cost (NIC) |
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Basic price of a drug, i.e. the
price listed in the Drug Tariff. Used in PACT reports and other analyses to present the
prescribing patterns of GPs, PCGs and HAs. |
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NIC standardises cost throughout
prescribing nationally. The NIC of any prescribed item is the same whoever the prescriber
may be.
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Actual (or `Cash') |
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Closer to the true price paid by
the National Health Service (NHS). This takes into account NIC minus the discount
dispensers are assumed to have received from their suppliers plus container fees.
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| Discounts
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Discount factor |
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The discount calculation in PMD
(formerly IPS) takes into account discounts across all dispensers. Community pharmacists
are assumed to receive a discount from their suppliers. The discount factor assumed for
individual pharmacies varies according to the number of items they dispense.
However, for the purposes of GP, PCG and HA prescribing budgets and statements, a national
average discount percentage is used, based on the total discount calculated. |
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Similar discounts exist for
dispensing practices.
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Hospital discount |
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The prices of drugs bought by
hospitals or Trusts are determined by negotiation. In some instances this is done by the
pharmaceutical company and the hospital pharmaceutical-purchasing manager or by the NHS
Supplies Authority on behalf of the hospital. Deals are normally based on bulk purchase.
Drug companies can provide items as `loss leaders' to promote that product's use in
primary care once initiated in hospital. |
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In the past, the promise of
exclusivity (i.e. an arrangement in which no similar drug produced by a competitor would
be stocked) was occasionally used to reduce contract price. Now, however, these linked
deals are contrary to European Union regulations. |
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| Incentive
scheme |
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Incentives should: |
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Reward improvements in patient
care and health outcome and link them to clinical governance. |
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Be internally aligned to avoid the
creation of perverse behaviours within the health system (i.e. avoid the possibility that
health bodies appear to be performing well while shifting costs or activity between
different bodies/budgets).
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All PCGs are required to run a
prescribing incentive scheme in which each practice will participate (HSC 1998/228).
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The scheme is underpinned by the
following principles: |
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To reward those PCGs (and their
constituent practices) who take on greater levels of responsibility and undertake it in a
clinically and cost effective manner. |
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To
operate at the point at which decisions are taken (i.e. reflect the alignment of clinical
and financial responsibility). |
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To reward performance based on
achieving higher quality care, effective clinical practice and best value for the resource
available. PCGs should ensure any incentive payments to practices are consistent with this
principle to ensure surpluses are not generated at the expense of effective patient care. |
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To operate in an integrated
fashion with the local clinical governance arrangements and alongside the incentive
arrangements in the other sectors of the new NHS. |
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To ensure a coherent package of
measures designed to reward performance that delivers improved care, and better and more
equitable health outcomes for patients. |
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To ensure the appropriate balance
between generating rewards for the effective development of services within the PCG
overall and the improvement of services at practice level. |
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To be simple to operate. |
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To be sufficiently attractive to
health professionals and PCG members to provide motivation to perform well. |
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To reward good performance at
practice level even if the PCG performance overall is poor (recognising that without such
performance the overall PCG performance would be worse). |
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To allow year-on-year improvements
in practice performance to be rewarded. |
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To provide incentives for good
performers to help poorer performers improve.
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| Virement
schemes |
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Projects that looked at innovative
ways of using prescribing budgets more effectively. Funds were vired (moved from one
budget to another) out of the prescribing budget into, usually, HCHS. Often used to
contract directly for the provision of medicines by a Trust, e.g. erythropoietin. In this
case the Trust would provide the patient with the drug directly and the GP would not be
required to prescribe (this process is now simpler to organise within the unified budget).
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| Contracting
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Medicines can be contracted for as
part of a wider process when dealing with hospital Trusts. The contract (or `Service Level
Agreement' (SLA)) should indicate precisely what service is being contracted for, under
which circumstances, to whom it is being provided, for what period and at what cost.
Clauses can be included for failure to supply the intended services. |
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This can be a very good method for
organising the provision of medicines that need to be initiated and monitored by hospital
specialists, and to contain such costs within an agreed financial envelope.
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| NHS Funding
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NHS Funding is split into two
distinct categories: |
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Part 1 NHS services/monies |
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See Hospital & Community
Health Services.
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Part 2 NHS services/monies |
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See Family Health Services. |
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| Organisational
terms |
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| Health Improvement
Plan (HImP) |
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A three year action plan to
improve local healthcare, lead by each HA, but involving Trusts, PCGs and local
authorities. It will provide the blueprint for the development and planning of health
services within a PCG and is based upon the annual report of the HA Director of Public
Health. The development of the HImP and its implementation will become one of the main
priorities for PCGs, against which they will also be performance managed
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| Clinical
Governance (CG) |
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Aligns clinical judgement with
national standards and local peer review.
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The ten points of clinical
governance from "The New NHS" (DoH, December 1997) are about ensuring:
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Quality improvement processes
(e.g. clinical audit) are in place and integrated with the quality programme for the
organisation as a whole. |
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Leadership skills are developed at
clinical team level. |
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Evidence-based practice is in
day-to-day use with the infrastructure to support it. |
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Good practice, ideas and
innovations (which have been evaluated) are systematically disseminated both within and
outside the organisation |
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Clinical risk reduction programmes
are in place. |
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Adverse events are detected,
openly investigated and learning applied. |
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Lessons for clinical practice are
systematically learned from the input of patients. |
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Problems of poor clinical
performance are recognised at an early stage and dealt with, both to prevent harm to
patients and to improve the practitioner's development. |
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All professional development
programmes reflect the principles of clinical governance. |
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The quality of data gathered to
monitor clinical care is of a high standard.
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Clinical governance is inclusive -
all health professionals working in practices and with other partners in care are
involved. It needs to gain the confidence of participants and therefore be carried out in
an atmosphere of openness and trust. In order to make clinical governance processes
effective, information about quality care should be shared, within the limits of
protecting patient confidentiality.
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| Probity/fraud
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Probity - `Tried virtue or
integrity; approved moral excellence; honesty; rectitude; uprightness.' Webster's Revised
Unabridged Dictionary.
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Probity is especially important
when dealing with public money, sponsorship and clinical trials. Guidance is contained in
HSG(93)5: Standards of Business Conduct for NHS Staff. Applies to all individuals working
within the NHS.
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There is much recent guidance
issued in respect of fraud and corporate governance responsibilities, which should be
consulted for further information. For example HSC1999/062 - Countering fraud in the
NHS: notification of possible disciplinary, civil or criminal proceedings; HSC 1999/082 -
Fraud countering fraud in the NHS; HSC 1999/105 - Corporate governance amendments to
example standing orders for NHS Trusts and example fraud policy and response plan. |
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| Fraud Investigation
Unit (FIU) at the PPA |
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The FIU was established in April
1996 on the direction of Ministers. Part of the PPA, the FIU investigates claims for
patient exemption from prescription charges and, where appropriate, recovers debts.
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The FIU makes enquiries into
alleged irregularities by chemists or doctors. In addition, the unit has a forgery and
counterfeiting bureau, and administers the pharmacy reward scheme.
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The unit staff can be contacted on
their hotline, 0800-068-6161 or via their web page: |
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| Pharmaceutical
Price Regulation Scheme (PPRS) |
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The PPRS is a voluntary (rather
than a statutory) arrangement in which confidential negotiations between the DoH and
individual drug companies determine the profit each company is allowed to make on its
medicine sales to the NHS in the next year.
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The terms of the scheme are
renegotiated periodically by the DoH and the Association of British Pharmaceutical
Industry (ABPI). To date in its negotiations, the DoH has three goals:
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To `secure the provision of safe
and effective medicines for the NHS at reasonable prices'
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To `promote a strong and
profitable pharmaceutical industry in the UK capable of such sustained research and
development expenditure as should lead to the future availability of new and improved
medicines'. It is in this capacity that the DoH acts as `sponsor for the industry'. |
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To `encourage in the United
Kingdom, the efficient and competitive development and supply of medicines to the
pharmaceutical markets in this and other countries'.
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The PPRS negotiations apply only
to brand name medicines and because the PPRS is an NHS scheme, it only covers medicines
prescribed on the NHS. Excluded from the scheme are generic medicines, private
prescriptions and medicines bought over-the-counter.
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The PPRS negotiations set a profit
target for each (large) drug company that has a major research or manufacturing base in
the UK and sells its products to the NHS. The profit target is the permitted return for
distribution to shareholders or staff, or for reinvestment in non-research components of
company development. The target is usually set at a proportion of the company's capital
employed in providing medicines to the NHS.
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In assessing permissible profit,
allowances are made for expenditure on: |
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Promotion |
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Information |
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Research and development |
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Manufacture and distribution |
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Administration.
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For promotional expenditure, each
company is permitted to spend an amount that is individually calculated for it; the
amount, therefore, varies from one company to another. Each company has a starting
allowance of £400,000 plus 6% of the value of its total sales to the NHS. The company is
also eligible for an individual product allowance based on a number of its products on the
market.
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If a company spends more than the
permitted amount on promotion, the excess is deducted when calculating allowances in the
next round of negotiations, so reducing the profit allowed for the following year. On
average, across all companies, the amount spent on promotion equates to around 9% of the
value of sales to the NHS.
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The PPRS is currently being
renegotiated. |
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| Nurse prescribing |
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Based upon the recommendations
contained in the Report of the Advisory Group on Nurse Prescribing 1989 (The Crown Report)
which advised Ministers on how nursing care in the community might be improved by the
introduction of nurse prescribing.
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First proposed in 1986, and
piloted in 1994 the Crown Report introduced a Nurse Prescribers' Formulary (initially a
formulary drawn up around what a district nurse would use) and rolled-out throughout
England from 1998. The Nurse Prescribers' Formulary is listed in part XVIIB of the Drug
Tariff and in the BNF.
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Nurse prescribing is mainly
`substitute' prescribing i.e. what GPs previously prescribed at the request of community
nurses, and therefore, aims to legitimise existing practise.
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Only nurses working in community
NHS Trusts, or for GPs as practice nurses, and who hold the Health
Visitor (HV) or District Nurse (DN) qualifications (or equivalents), and
who have successfully completed an approved prescribing training course are legally
entitled to prescribe.
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Nurses can only prescribe using
prescription forms FP10PN or FP10CN (see later).
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| National
Prescribing Centre (NPC) |
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The NPC is a health service
organisation, formed in April 1996 by the NHS Executive, following a review of centrally
funded support for prescribing and medicine use. The current aim of the NPC is `to facilitate the promotion of high quality, cost-effective prescribing
through a co-ordinated and prioritised programme of activities aimed at supporting all
relevant professionals and senior managers working in the new NHS'.
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The NPC delivers a wide range of
activities across the following five main areas of work: |
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Information
on Medicines: by helping to co-ordinate the provision of effective information
on medicines and prescribing related issues to audiences including HAs and their
prescribing advisers and GPs. The information is disseminated through various NPC
publications such as MeReC Bulletins and Briefings; Connect newsletters; Information
Resource documents; New Drugs in Clinical Development and New Medicines on the Market
Bulletins (in collaboration with the Drug Information Pharmacists Group, DIPG) |
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Training
and Education: by delivering a co-ordinated programme of events aimed at
supporting prescribing advisers and other senior HA professionals and managers; PCG leads,
managers and advisers; GPs and other relevant professionals across the NHS. This is
achieved through targeted therapeutic workshops, day seminars and national conferences. |
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Dissemination
of Good Practice: by ensuring that HAs, advisers, PCGs and through them their
GPs, have a clear understanding of how the wider prescribing agenda is developing and what
information and support on evidence-based healthcare, clinical effectiveness and medicine
use is potentially of value to the NHS both locally and nationally. This work builds on
the HA prescribing initiative database now available, password protected for HA use, on
the NPC's web site. Other relevant NPC publications include - `Medicines and the NHS: a
guide for Directors' and `GP Prescribing Support: a resource document and guide for the
new NHS'. See below for details of the NPC website. |
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Information
Technology: by helping in the development of information systems related to
prescribing, and by assessing the potential of new and emerging technologies to aid the
work of HAs, advisers, PCGs, Trusts and GPs. The NPC's work builds on developments such as
the `Toolkit' initiative produced in collaboration with the PPA and Prescribing Support
Unit (PSU), the Hospital Prescribing Information Project and the ePACT training programme.
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Informing
Research and Initiatives: by continuing to keep HAs, advisers and other
relevant NHS staff informed of key information emerging from both the NHS Research and
Development, and Health Technology Assessment initiatives.
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NPC website |
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| Prescription
Pricing Authority (PPA) |
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The PPA is a Special Health
Authority within the NHS. The PPA processes every prescription that is dispensed by any
pharmacy and dispensing doctors in England. In 1998 it processed over 500 million
prescription items at a total cash value of £4.5 billion. This figure represents
approximately 13% of the total NHS expenditure. Annually the authority issues in the
region of 450,000 paper based reports containing information on prescribing habits and
trends.
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The PPA main functions are: |
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Examination, investigation and
pricing of prescriptions dispensed in England. |
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Calculation of reimbursements due
to dispensing contractors in the primary care sector and payments to pharmacy contractors. |
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Prompt and regular provision of
information analysing costs and prescribing trends of GPs. |
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Compilation, publication and
distribution on a monthly basis of the Drug Tariff. |
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Administration of the NHS Low
Income Scheme Index. |
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Investigation in the primary
prescribing sector of fraud by patients and contractors, including the promotion of fraud
awareness and prevention.
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PPA website: |
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PPA Helpdesk |
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For problems relating to PPA
websites; contact the PPA Helpdesk on 0191 203 5050. |
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| The Prescribing
Support Unit (PSU) |
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